Mr. Osomatsu

The Matsuno sextuplets (leader Osomatsu, wannabe tough guy Karamatsu, straight man Choromatsu, cynical Ichimatsu, cheerfully stupid Jyushimatsu and lovable spoiled Todomatsu) are now in their 20s, still living together in the same house as NEETs. Their neighbors still include such eccentric characters as fish market idol Totoko, loud bucktoothed troublemaker Iyami, tiny rival Chiba, wacky inventor Dekapan, and giant mouthed glutton Dayon. Join the Matsuno siblings as they overcome mundane hurdles in their daily lives, such as finding employment, figure out who should pay the bar bill, and who should get the extra pastry!

Osomatsu-kun (1988)

The would-be hijinks of the mischievous Matsuno sextuplets are hijacked from episode one by colorful buck-toothed con man Iyami and Chibita, his bald munchkin sidekick. Nearly every episode is a standalone comedy cavalcade with the above cast as well as other quirky locals who show up in a number of different roles as the series shifts effortlessly between time periods and genres, but in most cases, Iyami and Chibita are front and center as partners in crime, a couple of sad sacks scraping by but carrying out scammy schemes in order to get rich quick. (Source: Discotek Media)

Pop Team Epic

Poputepipikku turns absurdist comedy up to eleven with its pop culture references and surreal hilarity. With two bonafide high school girl protagonists—the short and exceptionally quick to anger Popuko, and the tall and unshakably calm Pipimi—they throw genres against the wall and don't wait to see what sticks. Parody is interlaced with drama, action, crudeness, and the show's overarching goal—to become a real anime.

Tentai Senshi Sunred

The story revolves around the Tama River area, based mostly in Kawasaki City Kanagawa where battles are fought between the evil organisation Florsheim and the ally of justice Sunred. The twist is that Sunred (referred to most characters familiar with him as Red-san) is a rough-talking, violent and rude hero while the villains of Florsheim (led by General Vamp) are for the most part polite, conscientious and easy-going. Despite this, both sides still stay true to their roles, with Florsheim dedicated to destroying Sunred and taking over the world while Sun Red battles against them. Other evil organisations and heroes are also mentioned from time to time. Each episode is divided into various shorts of varying length. Most of the humour comes from the interactions of the characters, especially the main trio of Sunred, his girlfriend Kayoko and General Vamp. Kayoko and Vamp, for example, get along very well and she occasionally consults him about housework or cooking. In contrast, she and Sunred often argue like a long married couple. (Source: Wikipedia)

Excel Saga

Excel Saga is a one-of-a kind work of art that can only be described as the ultimate parody of anime. From the opening credits - a rather odd spoof of Japanese pop videos - to the ending song featuring Menchi the dog singing/barking a plaintive ballad while a human interpreter translates for viewers, nothing is sacred in the world of Excel Saga. (Source: ADV Films)

Doraemon

Nobi Nobita is a 4th-grade boy in Tokyo. One day, a round, blue cat-style robot (minus ears) pops up in his desk drawer. Nobita's great-great-grandson (or something) lives in the 22nd Century, but thanks to Nobita's mistakes, the entire family is living in poverty. To rectify this, Nobita's descendent is sent Doraemon back to the past, to help prevent Nobita from making mistakes. Of course this is a difficult task since Nobita is the weakest and least intelligent child in his class. Doraemon does, however, have a 4-dimensional pocket on his front, which contains cool gadgets from the future. With these toys, Doraemon will try to help Nobita. Unfortunately, Nobita also has the bad habit of misusing Doraemon's gadgets and landing himself in yet more trouble? (Source: AnimeNfo)