Azumanga Daioh

Ten year old child prodigy, Chiyo Mihama, is finding it tough fitting in at high school with the girls five years her elder: Osaka (dimwitted with a weird take on the world), Tomo (a powder keg that goes off at a moment’s notice), Kagura (the competitive athlete of the bunch), Yomi (the hothead), and Sakaki (timid and obsessed with a love of animals that isn’t reciprocated). Together with their teacher, they navigate the rough waters and fun times of high school. (Source: Sentai Filmworks)

Asobi Asobase - workshop of fun -

Olivia is a blonde-haired beauty who was born and raised in Japan, but can’t speak any English. Despite always acting serious and as an intellectual, Kasumi is a bespectacled girl with short hair, who also can’t speak English. Finally, there’s the pig-tailed Hanako, who’s cheerful but can’t seem to become a normie. The three middle schoolers end up making a “Players’ Club”?! The ultimately cute, ultimately fun and hilarious teenage girls’ comedy is about to begin! (Source: Crunchyroll)

YuruYuri

Right after starting middle school, Akari Akaza joins the Amusement Club which is composed solely by her two childhood friends, Kyouko Toshinou and Yui Funami. Chinatsu Yoshikawa, Akaza's classmate, becomes a member after finding out about the dissolution of the Tea Club. The Amusement Club, situated at the tea room facility since the Tea Club disbanded, has no clear purpose, being free for the girls to do whatever they want. (Source: Anime News Network)

Yuyushiki

Everyone knows you can learn a lot on the internet, and some of it is even true. But if you want to know what's REALLY going on and important, then there's just one place to go: the computer club! Okay, so maybe it's not the club itself, but the three girls you're most likely to find there. And maybe they do spend more time chatting about their social lives and debating things like the virtues of ketchup versus mayonnaise than they do learning about the ins and outs of a keyboard, but whatever they're up to, it's sure to put a smile on your face. (Source: Sentai Filmworks)

Joshiraku

Marii, Kigurumi, Tetora, Gankyou, and Kukuru deserve a round of applause for keeping the art of Rakugo alive! What’s their secret? Witty, absurd banter of course! These five friends always have something to talk about, no matter how silly the topic. (Source: VRV)

Kill Me Baby

Kill Me Baby is the touching story of Yasuna, a normal (?) high school girl, and Sonya, her best friend who happens to be an assassin. Unfortunately, little Sonya's trained assassin instincts often work against her and others in her daily high school life, as Yasuna's often-broken wrist can attest to. She just wanted a hug, but she ended up with a broken neck. Isn't it sad? No, it's hilarious. Not even Yasuna's intense ninja training can prepare her for the exciting adventures in this explosive 4-panel manga adaptation.

Cromartie High School

Is this the real life? Is this just fantasy? The only thing for certain is that for Kamiyama, Cromartie High School is his reality. And what a surreal reality it is. Because this is where the toughest, meanest (and often dumbest) students are sent to do time. At Cromartie, purple-mohawked bruisers and pencil-chomping street thugs are just part of every day life. And so is a 400-pound gorilla. And a macho brute named Freddie who travels with his own theme music. And, of course, Mechazawa, the student voted most likely to need an oil change. So pack your bags, put on your best tough-guy swagger, and get a lesson in insanity from the hilarious losers at Cromartie High. This is one class you won't ever want to cut. (Source: Discotek)

Plastic Elder Sister

Based on Kurii Cha's gag comedy manga, Plastic Nee-san is a very short anime that follows a third-year high school girl who likes building plastic models and the wacky conversations she has with her fellow club members.

Arakawa Under the Bridge

Ko Ichinomiya's family motto is "Never be indebted to anyone," but after losing his pants and falling into the Arakawa River, he quickly finds himself in debt to his savior, the cutely insane Nino (who happens to live under the bridge). To repay her, he vows to help her with her desire to "experience love." Along the way he'll meet the river's other residents, including a hot-blooded kappa, a Sister in drag, and a literal rock star. Sorry, Ko—when you fell into that river, I guess you really got in over your head! (Source: NIS America)

Keep Your Hands Off Eizouken!

First year high schooler Midori Asakusa loves anime so much, she insists that "concept is everything" in animation. Though she draws a variety of ideas in her sketchbook, she hasn't taken the first step to creating anime, insisting that she can't do it alone. The producer-type Sayaka Kanamori is the first to notice Asakusa's genius. Then, when it becomes clear that their classmate, charismatic fashion model Tsubame Mizusaki, really wants to be an animator, they create an animation club to realize the "ultimate world" that exists in their minds. (Source: Crunchyroll)

K-ON!

Hirasawa Yui, a young, carefree girl entering high school, has her imagination instantly captured when she sees a poster advertising the ‘Light Music Club’. Being the carefree girl that she is, she quickly signs up. However, Yui has a problem, she is unable to play an instrument. When Yui goes to the clubroom to explain, she's greeted by the other members: Ritsu, Mio and Tsumugi. Although disheartened at Yui’s lack of musical know-how, they still try to convince her to stay to prevent the club’s disbandment. After playing Yui a short piece which re-ignites her imagination, they succeed in keeping their new member and guitarist. Along with the tasks of school and homework, Yui begins to learn the guitar with the help of the other band members, experiencing many mishaps along the way. However, with the school-festival drawing near and Yui getting stuck with her practice, will the Light Music Club be ready in time for their debut? (Source: MAL Rewrite)

Minami-ke

There are three of the Minami sisters: Haruka, Kana and Chiaki, who have an average life. The girls only have each other to depend on and help each other get through everything from love confessions to cooking. (Source: Anime News Network)

AIURA

The story centers around Amaya, Iwasawa, and Uehara—three "annoying, spirited high school girls with zero motivation"—and their classmates. Their daily life is "what happens when there is nothing happening." (Source: Anime News Network)

Hayate the Combat Butler

Hayate Ayasaki's life wasn't great, but when he loses the job he used to support his good-for-nothing family, and his deadbeat parents sell him to the Yakuza for cash, it really hits rock bottom! Faced with having to pay off the huge debt before he's converted into black market organ parts, a desperate Hayate decides to kidnap oddball heiress Nagi Sanzenin for ransom... but when even that goes wrong and he accidentally ends up rescuing Nagi from other kidnappers, it turns out that Hayate is the bodyguard that Nagi has been looking for! So now he's the Sanzenin family's butler, and… maybe… it might be the start of a potential romantic relationship… assuming Hayate can survive the on-the-job training, of course. (Source: Sentai Filmworks)

Sabagebu! - Survival Game Club!

Momoka's family moves a lot, so she's always "that new girl" and the schools she's attended have all blurred together. Until her first day at Aogiri High, that is, where she's rescued by an armed vigilante, assaulted by a platypus, and coerced into joining a secret organization of gun-toting female commandos. Okay, maybe that last one is really just the school's survival club, but the platypus is real and so are the extremes that club president Miou is willing to execute to recruit Momoka. Can uber-jaded Momoka's body armor-clad heart resist the charms of a girl who's all too ready to whip out her twin Desert Eagles in defense of another girl's virtue? Especially when it turns out that Momoka has her own talent for air pistols and senseless violence? (Source: Sentai Filmworks)

Himouto! Umaru-chan

The sibling gag comedy manga centers around Umaru, Taihei's little sister who boasts beautiful looks as well as prowess in both school and sports. However, "Himouto" (beautiful little sister) has a certain secret. (Source: Anime News Network)

AHO-GIRL

Yoshiko Hanabatake is an idiot beyond all belief. Somehow managing to consistently score zeroes on all of her tests and consumed by an absurd obsession with bananas, her senseless acts have caused even her own mother to lose all hope. Only one person is up to the task of keeping her insanity in check: childhood friend Akuru "A-kun" Akutsu. Though he bemoans the ridiculous behavior he has to endure, the studious but terrifying A-kun is always ready to put an end to any stupidity Yoshiko gets up to, with no qualms about using physical force. Unfortunately, no matter how many times he attempts to knock some sense into her, the girl bounces right back to her usual shenanigans, even dragging in some other eccentrics along for the ride. Try as he might to rein in her nonsense, every moment is unpredictable with Yoshiko and her profound idiocy on the loose. (Source: MAL Rewrite)

Three Leaves, Three Colors

Futaba Odagiri is the energetic transfer student who befriends Teru Hayama, the class president who is meaner than she looks, and Youko Nishikawa, a former rich girl who still acts like a princess. Three very different girls who only share one thing: the kanji for leaf in their names. Balancing school and life is hard enough, but what about dealing with clashing personalities on top of it all?  (Source: Crunchyroll)

My Neighbors the Yamadas

Join in the adventures of the quirky Yamada family -- from the hilarious to the touching -- brilliantly presented in a unique, visually striking comic strip style. Takashi Yamada and his wacky wife Matsuko, who has no talent for housework, navigate their way through the ups and downs of work, marriage and family life with a sharp-tongued grandmother who lives with them, a teenage son who wishes he had cooler parents, and a pesky daughter whose loud voice is unusual for someone so small. Even the family dog has issues! (Source: Disney)

Kyou no Go no Ni (2008)

Following the line of the precedent OVAs (of the same name) This anime goes around the normal lifes of some elementary school (5th grade, 2nd class room) kids and their adventures, while turning to teens. Their games, stupid jokes, and the misunderstadings around their premature attraction to the opposite sex. Ryota Satou is the main character here, but his friends are almost as important as him since the school wouldn't be the same without them, specialy the girls who the majority of time appear to be mature by their ages but in the ends they are as childish and even more "dangerous" than the boys. (Source: Anime News Network)