RahXephon

In the year 2012 Japan was invaded by the Mu. Human-like beings from another dimension with blue blood. In the year 2015 Tokyo is attacked by invaders, who are repelled by a humanoid weapon called a Dolem. During the chaos, Ayato Kamina meets Reika Mishima, a classmate. During that same day, he is attacked by government officials but a woman named Haruka comes to his rescue, informing him that she was sent to get him by the Organization TERRA, and that Tokyo had been sealed in a time rift where time flows one third as fast as the outside world. He flees from Haruka onto a train where he sees Reika once more. Arriving at the Room of Rah, he follows her to a tremendous egg where the Dolem RahXephon is hatched from, and upon her singing his mother appears atop the Dolem that had stopped the TERRA Invasion. In the battle Ayato's mother is injured, and Ayato flees Tokyo Jupiter with Haruka upon seeing his mother's blue blood.

Neon Genesis Evangelion

In the year 2015, the Angels, huge, tremendously powerful, alien war machines, appear in Tokyo for the second time. The only hope for Mankind's survival lies in the Evangelion, a humanoid fighting machine developed by NERV, a special United Nations agency. Capable of withstanding anything the Angels can dish out, the Evangelion's one drawback lies in the limited number of people able to pilot them. Only a handful of teenagers, all born fourteen years ago, nine months after the Angels first appeared, are able to interface with the Evangelion. One such teenager is Shinji Ikari, whose father heads the NERV team that developed and maintains the Evangelion. Thrust into a maelstrom of battle and events that he does not understand, Shinji is forced to plumb the depths of his own inner resources for the courage and strength to not only fight, but to survive, or risk losing everything. (Source: AniDB) Note: Later releases include edited versions of Episodes 21-24 called the "Director's Cut" with some visual editing and adding extra scenes that appeared in the theatrical recap 'Death'.</i>

Fafner

Tatsumiyajima is the central island in the middle of a small cluster of islands, in a sleepy backwater of the Japanese isles. Not much happens there, and the island's young people go to school knowing that their lives are likely to remain peaceful and undisturbed. Or so they have been taught... but the truth is different. The fate of mankind is on the line, and Tatsumiyajima is the last line of defense against a hostile and incomprehensible enemy. At the center of it all, fighting for Humanity's continued existence, is the giant robot Fafner, the dragon that guards this final treasure of mankind. (Source: Anime News Network) Note: The last episode aired with a runtime of ~48 minutes as opposed to the standard 24 minute long episode. In the DVD release and subsequent home video releases of the series, the final episode was split into two separate ~24 minute long episodes.</i>

Zegapain

Kyo, an avid swimmer tries his best to keep the high school swimming club going, which is pretty hard when he's the only member. Facing the prospect of the club being closed by the student council, he tries to enlist beautiful Misaki to act in a promo video, shot by his good friend Ryoko, in a bid to start a recruitment drive. She agrees but only if he pilots a mecha under the wing of Celebrum, a resistance organisation fighting to destroy Deutera Areas formed on Earth by the aliens Gards-orm. He agrees but finds it all strangely familiar as if he's done it before... (Source: Anime News Network)

Space Runaway Ideon

From the continuing reclamation of the ruins of the planet Solo, mysterious mechas are excavated. But suddenly, an alien called Buff Clan attacks seeking the limitless energy “Ide.” The earthlings are backed into a corner, when the three mechas piloted by the earth boy Yuki Cosmo and others fuse together. Becoming the giant robot Ideon, they use their incredible power to fight back against Buff Clan. (Source: Sunrise)

Bokurano

During a summer camp, 15 children, 8 males and 7 females, find a grotto by the sea. Deep within they discover working computers and some electronic equipment, and later the owner, a man called Kokopelli. Kokopelli claimed to be a programmer working on a brand new game, in which a large robot has to defend the Earth against alien invasions. He persuades the children to test the game and sign a contract. All but one of them signs, barely a moment later they mysteriously awaken on the shore believing what happened was just a dream. (Source: Anime News Network)

The Big O

Paradigm City is a place without a past. 40 years ago, something happened that wiped the memories of everyone in it. Unfortunately, the people of Paradigm City were very busy before then, making Megadueses (giant robots) and monsters. People who were born after the memory wipe are gaining/recovering memories of the past and using them to build newer threats. With the help of The Big O (a faithful giant robot), his butler Norman and the android Dorothy, Roger Smith keeps Paradigm City safe. As problems mount and more memories surface, Roger's past and Paradigm's future begin to become suspect...

Gunbuster

In the very near future, a race of huge, insect like aliens is discovered traveling the galaxy. These aliens seem dedicated to the eradication of the human species as it takes its first steps away from the solar system, and they are getting closer and closer to Earth. Humanity has responded by developing spacegoing battleships and giant fighting robots. These robots are piloted by the best and brightest of Earth's youth, picked from training schools around the world. The story begins in the year 2023, not long after the first battles with the aliens, and centers on young Noriko Takaya. Although Noriko's father was a famous Captain in the space fleet who was killed during one of the first battles of the war, her own talents as a pilot are questionable. Nonetheless, she has entered a training school. Through the series Noriko, joined by the beautiful and talented Kazumi Amano, will fight to overcome the trauma of war, the doubts of her peers, and her own lack of confidence. (Source: AniDB)

Aquarion

When the Shadow Angels invade after 12,000 years of slumber, humanity is held captive by fear and sheer alien dominance. Eleven years after the Great Catastrophe decimated the world, most of those left alive are scavengers, dirty and starving in the streets. There is hope, however: Mechanical Angel Aquarion! Powered by three souls intertwined, a rare breed of pilot takes the controls. Known as Elements, one among them must rise if mankind is to survive. Prophecy is being fulfilled as the end of the world approaches... Through a swirling cloud of love, betrayal, loss and destiny, the last hope for the new century arrives and takes flight! (Source: Funimation)

Gasaraki

The flames of war explode in the Middle East as two shadow forces unleash monstrous new weapons of mass destruction! But in a world in which giant robots are real, the most dangerous weapon of all lies buried within a human mind. Yushiro, the fourth son of the mysterious and powerful Gowa family, finds himself at the center of events that will change the future of mankind forever! Nothing can prepare the human race for what is about to be unleashed in Gasaraki! (Source: Sunrise)

Brain Powerd

In the not so distant future much of the earth has been submerged under the sea or destroyed by earthquakes. At the center of the turmoil is the mysterious Orphan. Orphan may or may not be the original cause of the cataclysms. Orphan's goal is to raise a ship hidden deep beneath the sea to the surface, but doing so would result in the destruction of all humans except for the small number which are loyal to Orphan. Orphan's agents pilot mysterious mecha known as Grand Cheres, and search the world for mysterious, giant disks which occasionally appear, flying at high speeds and wrecking much of the countryside, or cities, when they hit the ground. After a dying disc almost kills Hime, a Brain Powerd is born from the disc. Brain Powerds are another type of Mecha, similar to but not the same as Grand Cheres. Hime becomes the Brain Powerd's pilot, forming a symbiotic relationship with the living mecha and joins an International Organization dedicated to stopping Orphan, or at the very least saving humanity should Orphan succeed.

Akira

It's the year 2019, thirty-one years have passed since the start of World War III. A top-secret child with amazing powers of the mind breaks free from custody and accidentally gets a motorcycle gang involved in the project. This incident triggers psychic powers within one of the gang members, Tetsuo, and he is taken by the army to be experimented on. His mind has been altered and is now on the path of war, seeking revenge on the society that once called him weak. (Source: FUNimation)