Yu Yu Hakusho: Ghostfiles

Urameshi Yusuke, 14 years of age, is about as troublesome and violent as teenagers come. He is constantly ditching school, causing trouble, and getting into numerous fights everyday. One day however, he does the unexpected, sacrificing himself to save a young child. Such an action, was never ever expected, especially coming from someone as troublesome as Urameshi Yusuke. The afterlife is not prepared for Yusuke, as they never thought he would make such a sacrifice. Nowhere to go, and dead, Yusuke becomes a ghost and must earn his way back into existence. Yusuke is "employed" by Koenma, who is in charge while his father and ruler of the afterlife, King Enma, is away. Under Koenma's command, Yusuke helps to stop menacing demons that threaten the lives of people everywhere; whether by stealing priceless and invaluable items and destructive weapons, or by wreaking havoc on humans everywhere. Throughout Yusuke's journey, he is usually joined by; his arch-rival, and local bully, Kuwabara Kazuma. He is also joined by two demons named Hiei and Kurama, whom are ex-convicts of the afterlife that managed to escape from Koenma. This group of unlikely allies goes on to participate and struggle in battles that have outcomes that determine the fate of humanity! (Source: AniDB)

JoJo's Bizarre Adventure (TV)

Beginning its tale in 19th century England, young aristocrat Jonathan Joestar finds himself locked in bitter rivalry with Dio Brando, a low-born boy who Jonathan's father took under his wing after the death of Dio's father. Discontent with his station in life, Dio's fathomless lust to reign over all eventually leads him to seek the supernatural powers of an ancient Aztec stone mask in the Joestar's possession—an artifact that will forever change the destiny of Dio and Jonathan for generations to come. Fifty years later, in 1938 New York City, Jonathan's grandson Joseph Joestar must take up his grandfather's mission and master the abilities necessary to destroy the stone mask and its immensely powerful creators who threaten humanity's very existence, the Pillar Men. (Source: Anime News Network)

Bleach

Ichigo Kurosaki is a rather normal high school student apart from the fact he has the ability to see ghosts. This ability never impacted his life in a major way until the day he encounters the Shinigami Kuchiki Rukia, who saves him and his family's lives from a Hollow, a corrupt spirit that devours human souls. Wounded during the fight against the Hollow, Rukia chooses the only option available to defeat the monster and passes her Shinigami powers to Ichigo. Now forced to act as a substitute until Rukia recovers, Ichigo hunts down the Hollows that plague his town.

Fullmetal Alchemist: Brotherhood

"In order for something to be obtained, something of equal value must be lost." Alchemy is bound by this Law of Equivalent Exchange—something the young brothers Edward and Alphonse Elric only realize after attempting human transmutation: the one forbidden act of alchemy. They pay a terrible price for their transgression—Edward loses his left leg, Alphonse his physical body. It is only by the desperate sacrifice of Edward's right arm that he is able to affix Alphonse's soul to a suit of armor. Devastated and alone, it is the hope that they would both eventually return to their original bodies that gives Edward the inspiration to obtain metal limbs called "automail" and become a state alchemist, the Fullmetal Alchemist. Three years of searching later, the brothers seek the Philosopher's Stone, a mythical relic that allows an alchemist to overcome the Law of Equivalent Exchange. Even with military allies Colonel Roy Mustang, Lieutenant Riza Hawkeye, and Lieutenant Colonel Maes Hughes on their side, the brothers find themselves caught up in a nationwide conspiracy that leads them not only to the true nature of the elusive Philosopher's Stone, but their country's murky history as well. In between finding a serial killer and racing against time, Edward and Alphonse must ask themselves if what they are doing will make them human again... or take away their humanity. (Source: MAL Rewrite)